Paper 8 December 2022

Antibiotic Cycling Affects Resistance Evolution Independently of Collateral Sensitivity

Drug cycling, based on collateral sensitivity is believed to be a promising strategy to increase the lifespan of our currently available antibiotics. However, it is not clear to which extent this decreased resistance evolution is solely due to collateral sensitivity. Therefore, Pauline Brepoels and Kenny Appermans examined the impact of additional mutational interactions in the genetic background beyond collateral sensitivity on further resistance evolution.