Collaboration

We are very open to new collaborations with academic or industrial partners on any research topics related to our research lines on social interactions, resistance evolution and monitoring of microbial communities.

Specifically, our interdisciplinary platform for the development of chemicals and coatings with activity against detrimental microbial communities (including biofilms) could be a valuable basis for collaboration.

We are currently participating in the following multi-partner projects: Bisceps (FWO SBO), Baratom (VLAIO LA-trajectory), Epiresist (FWO project), Defensico (KU Leuven C2), Clean-coat (KU Leuven C3), Bioclean (H2020 MSCA ITN) and the Flemish Scientific Research Network on Biofilms (FWO WOG), and have participated in several recently finished projects: NEMOA (IWT SBO), Coatim (FP7), SMART Release (KU Leuven IDO) and Killfilm (Flanders' Food).

This platform relies on the expertise of several research groups within and outside the KU Leuven and includes:

Screening platform

  • In vitro biofilm & toxicity
  • In silico: molecular modelling and datamining
  • In collaboration with:
    • M. De Mayer (KU Leuven)
    • A. Voet (KU Leuven)
    • L. De Raedt (KU Leuven)
    • J. Balzarini (KU Leuven)
    • ...

Chemical synthesis

  • Novel synthesis pathways
  • Upscaling
  • Immobilization
  • In collaboration with:
    • E. Van der Eycken (KU Leuven)
    • P. Chaltin (CD3 – CISTIM)
    • D. De Vos (KU Leuven)
    • F. Pertusati (Cardiff Univ)
    • ...

Mode of action & resistance

  • GFP promoter fusions
  • Omics approaches
  • Experimental evolution
  • In collaboration with:
    • K. Marchal (UGent)
    • R. Jelier (KU Leuven)
    • K. Foster (U Oxford)
    • J. Van Impe (KU Leuven)
    • ...

Towards application

  • Anti-biofilm coatings
  • Delivery (magnetic nanoparticles)
  • Combination therapy
  • Real life biofilms
  • In collaboration with:
    • K. Thevissen, J. Michiels (KU Leuven)
    • D. De Vos (KU Leuven)
    • T. Verbiest (KU Leuven)
    • K. De Reu (ILVO)
    • A. Verplaetse (Tech Campus Gent)
    • H. Rediers (Tech Campus De Nayer)
    • L. Wittemans (PC Groenteteelt)
    • P. Van Dijck (KU Leuven)
    • W.J. Metsemakers (UZLeuven)
    • ...

In silico design and screening of antimicrobial compounds:

Medium throughput in vitro screening for antimicrobial compounds:

Chemical synthesis and structure-activity-relationship of antimicrobial agents:

Molecular mode of action determination, including target identification, via complementary approaches:

Development of delivery strategies for antimicrobial compounds:

Towards application: