News

Paper

Evolution-proof inhibitors of public good cooperation: a screening strategy inspired by social evolution theory

Congratulations to Maries, Mathieu and Bram for their review/methods paper in FEMS Microbiology Reviews! In this paper we provide an extensive evaluation of factors that determine the evolutionary robustness of public good inhibiting strategies. We use the outcome of this analysis to propose a 5-step strategy that allows to identify novel evolution-proof antimicrobial strategies targeting public goods and that takes potential pitfalls already into account in the first stages of screening.

Announcement 9-11 May 2022

Coexistence in yeast

Tom presented a poster on how permissive aggregative group formation favors coexistence in yeast at Biofilms10, Liepzig.

Announcement 6 May 2022

Seminar at the University of Zurich

Hans gave a presentation at the university of Zurich on 'cooperation and competition in biofilms as novel targets for antimicrobial treatment'. Thank you to Rolf Kümmerli for the kind invitation!

Paper January 2022

In vitro models for vascular graft coating

Hozan published a systematic review on 'Pre-clinical in vitro Models of Vascular Graft Coating in the Prevention of Vascular Graft Infection: A Systematic Review'.

Group News 21 December 2021

Horizon Europe project

The MiCA lab had the honor to obtain a coordinator project (Triple-A-COAT) in the highly competitive HORIZON-CL4-2021-RESILIENCE-01 call. This multi-partner project (four research institutions and nine companies) will aim to develop a sustainable, safe and biobased antimicrobial, antifungal and antiviral nanocoating platform.

Group News 21 December 2021

Congratulations Maries!

Maries has successfully defended her PhD on 'inhibiting bacterial cooperation as an evolutionarily robust anti-biofilm strategy'. She will unfortunately be leaving us but we wish her all the best in her future career and life.

Group News 18 November 2021

Ines won third place at the ie-net competition 2021

Ines won third prize at the ie-net competition 2021 with her master thesis 'Pro- and Antibiotics, A golden combination against bacterial infections?'.

Group News 3 October 2021

Mathieu Joos won the student research award

After giving a presentation and facing the challenging questions of the jury and audience, Mathieu was declared the winner of the VBI Student Research Awards 2021 based on his master thesis 'Inhibition of public good production in Salmonella biofilms: An antimicrobial strategy that selects against resistance in vivo?.

Announcement

Presentation and panel discussion at the Montana Biofilm Science & Technology Meeting

Hans gave a presentation on 'the biofilm matrix as a cooperative and competitive trait' and participated in a panel discussion on 'uncovering the hidden potential and known challenges of the biofilm matrix'.

Group News July 2021

Lynn received the Baekeland mandate

We are proud to announce that Lynn received the Baekeland mandate for her project on anti-biofilm sheathing for medical devices. For this, she will be working closely together with the start-up company Amynas on their third-generation implants.

Paper July 2021

In vivo models for vascular graft coating

Hozan published a systematic review on 'Pre-clinical in vivo Models of Vascular Graft Coating in the Prevention of Vascular Graft Infection: A Systematic Review.'

Group News

Importance of antibiotic gradients

Pauline presented a poster on the importance of antibiotic gradients and epistasis in drug cycling strategies at the World Microbe Forum.

Group News June 2021

MiCA members in the spotlight in Bio-ingenieus

Curious about what we are doing? Maries and Tom’s work on Salmonella biofilm formation in C. elegans is highlighted in Bio-ingenieus, Journal of the Faculty of Bioscience Engineering (KU Leuven) (p. 27).

Paper 18 May 2021

Review on silver-coated vascular grafts

Hozan published a systematic review of preclinical data regarding commercial silver-coated vascular grafts in the Journal of Vascular Surgery.

Paper 21 April 2021

Improved anti-biofilm coating for orthopedic implants

Guglielmo published a paper on an improved 2-aminoimidazole based anti-biofilm coating for orthopedic implants: activity, stability, and in vivo biocompatibility in Frontiers of Microbiology.

Paper 11 February 2021

Aminoimidazoles as potent inhibitors in breweries

Lene and Jolien published a paper on 2-aminoimidazoles as potent inhibitors of contaminating brewery biofilms in Biofouling.

Group News 21 December 2020

Congratulations Bram!

Bram has successfully defended his PhD on competition sensing: molecular mechanisms and therapeutic potential. He will be staying with us at MiCA and will be working as a post-doc on optimization of probiotics via experimental evolution.

Group News

Thijs received the VLAIO innovation mandate

We are proud to announce that Thijs received the innovation mandate for his project on the valorisation of novel anti-biofilm inhibitors.

Paper 11 December 2020

Pseudomonas as biocontrol agent against Salmonella

Sharon and Bram published a paper on Pseudomonas putida as a potential biocontrol agent against Salmonella Java biofilm formation in the drinking water system of broiler houses in BMC Microbiology. Thank you to Koen De Reu and Marc Heyndrickx at ILVO for the nice collaboration!

Paper December 2020

Agaric acid reduces Salmonella biofilm

Bram and Tom published an article on how agaric acid reduces Salmonella biofilm formation by inhibiting flagellar motility in Biofilm.

Announcement 4 December 2020

Modelling dynamics after antimicrobial treatment

Luka presented a poster on modeling the dynamics of different bacterial populations in various environmental conditions when subjected to antimicrobial treatment at the Virtual Bioinformatics Student Symposium of the RSG Belgium.

Paper October 2020

Phosphate prodrugs as novel antimicrobials

Thijs, David and Xabier co-authored a paper on drug repurposing: phosphate prodrugs of anticancer and antiviral FDA-approved nucleosides as novel antimicrobials in the Journal of Antimicrobial Chemotherapy. Thank you to Michaela Serpi and Fabrizio Pertusati at Cardiff University for the nice collaboration!

Paper 6 August 2020

Contract agent on biofilms and their visualization

Xabier co-authored an article on the study on the effect of contrast agent on biofilms and their visualization in porous substrate using X-ray mu CT in Applied Sciences. This paper is based on a collaboration with Abhishek Shastry and Matthieu Boone at UGent within the frame of the Bioclean project.

Announcement January 2020

Aminoimidazoles inhibitors in breweries

Lene and Jolien presented their work on 2-aminoimidazoles as potent inhibitors of brewery biofilms at the 25th National Symposium for Applied Biological Sciences.

Announcement

EPS inhibition as robust anti-biofilm strategy

Maries presented her work on inhibiting EPS production as an evolutionarily robust anti-biofilm strategy at the 21st Gut Day Symposium.

Group News November 2019

Jolien goes to the finals!

Jolien is a finalist in the ie-net prices 2019) with her master thesis ‘Do Salmonella bacteria also divide chores?’.

Announcement April 2019

Influence gradients on resistance development

Pauline presented her work on the influence of antimicrobial gradients on the development of antibiotic resistance at the 5th Workshop on Bacterial and Fungal Biofilms.

Paper

Biofilm bacteria use stress responses to detect and respond to competitors. Current Biology.

Bram and Stefanie published a paper on 'Biofilm bacteria use stress responses to detect and respond to competitors' in Current Biology. This paper is the result of a collaboration with The Foster Lab at the University of Oxford.

Paper

Inhibiting bacterial cooperation is an evolutionarily robust anti-biofilm strategy. Nature Communications.

Lise, Kenny and Maries published a paper on 'Inhibiting bacterial cooperation as an evolutionarily robust antibiofilm strategy' in Nature Communications. This paper is the result of a collaboration with The Foster Lab at the University of Oxford.

Announcement

Talk on UZLeuven vascular symposium

Hans gave a talk on '2-aminoimidazole inhibitors of biofilm formation' at the 29th Vascular Symposium (Leuven, Belgium) organized by the UZ Leuven Department of Vascular Surgery.

This presentation frames within a collaboration with dr. Hozan Mufty (UZ Leuven) part of whose PhD research focuses on testing biofilm inhibitor coatings for vascular devices.

Group News

Bram’s work on competition sensing highlighted in Bio-ingenieus, Journal of the Faculty of Bioscience Engineering

'Bacterial competition: what doesn’t kill them makes them stronger'.

Announcement

Presentation at International Biofilm Summit

Hans presented work on antimicrobial tolerance of brewery biofilms to an audience of food microbiologists and cleaning and disinfection companies at the IBS 2019 conference in Parma, Italy.

Announcement

Three talks at Eurobiofilms - October 2019 - Glasgow

Bram talked about how biofilm bacteria use stress responses to detect and respond to competitors.

Hans gave a talk on inhibiting EPS production as an evolutionarily robust anti-biofilm strategy.

Xabier was awarded a short talk in the Elsevier PRIZE elevator session on responses to competition in Staphylococus aureus – Pseudomonas aeruginosa biofilms.

www.eurobiofilms2019.com

Paper

Competitive release enhances antimicrobial tolerance

Ilse published a paper on 'The influence of competitive inter-species interactions on antimicrobial tolerance in multispecies brewery biofilms' in The ISME journal.

Paper

A covalent imidazole coating to prevent biofilm formation on orthopedic implants

Elien published a paper on 'An antibiofilm coating of 5-aryl-2-aminoimidazole covalently attached to a titanium surface' in J Biomed Mater Res B Appl Biomater. This paper is the result of collaborations in the frame of the FP7 EU project COATIM and the IWT SBO project NEMOA.

Group News

Student research award for Pauline Brepoels

Pauline Brepoels is finalist of the VBI Student Research Awards 2018 based on her master thesis 'Antibiotic gradients influence the development of antibiotic resistance'.

Group News

MICA Lab highlighted in Bio-ingenieus – Journal of the Faculty of Bioscience Engineering

'Oplossingen voor antimicrobiële resistentie: een focus op microbiële gemeenschappen'.

Paper

Impedimetric fingerprinting of biofilms using multielectrode arrays

Together with imec, we published a paper on 'Impedimetric fingerprinting and structural analysis of isogenic E. coli biofilms using multielectrode arrays' in Sensors and Actuators B: Chemical.

Announcement

ASM Meeting report

Bram, Ilse and Hans drafted the meeting report of the American Society for Microbiology Conference on 'Mechanisms of Interbacterial Cooperation and Competition', held in Washington DC, 1 to 4 March 2017.

Paper

Review paper on drug repurposing

Ansie published a review paper on 'Repurposing of nucleoside- and nucleobase-derivative drugs as antibiotics and biofilm inhibitors' in Journal of Antimicrobial Chemotherapy.

Paper

Triggered antibiofilm compound release from MOFs

Together with the De Vos Lab, we published a paper on 'Smart Metal–Organic Framework Coatings: Triggered Antibiofilm Compound Release' in ACS Appl. Mater. Interfaces.

Announcement

Talk on competition sensing at ASM conference

Hans presented research on 'competition sensing' at the ASM Conference on 'Mechanisms of Interbacterial Cooperation and Competition'. Washington DC, US, 1 to 4 March 2017.

Paper

Fine-tuning anti-biofilm activity of imidazoles

Elien published a paper on 'Modulation of the Substitution Pattern of 5-Aryl-2-Aminoimidazoles Allows Fine-Tuning of Their Antibiofilm Activity Spectrum and Toxicity' in Antimicrob Agents Chemother. This paper is the result of collaborations in the frame of the FP7 EU project COATIM and the IWT SBO project NEMOA.

Announcement

Keynote talk on biofilm evolution at 3rd BIBR meeting

Hans gave a keynote talk on 'experimental evolution in biofilm populations' at the 3rd meeting of the BIBR group. Liège, Sart Tilman, Belgium, 8 September 2016. This talk was based on our recent paper in FEMS microbiology reviews.

Announcement

Talk on evolution-proof drugs at ASM conference

Lise presented her research on 'evolution-proof drugs' at the 2nd ASM Conference on Experimental Microbial Evolution. Washington DC, US, 4-7 August, 2016.

Group News

Our art in KU Leuven Campuskrant

Beeldige wetenschap: Pootafdruk van dinosaurus? Rotspartij met mos?

Group News

The lab on television

The Lab was portrayed in a reportage on innovation in the province of Vlaams-Brabant broadcasted on ROB television in November 2012.

Group News

Award for best exploitation plan in LRD tech transfer competition

21 teams presented their exploitation plan in the frame of the training course on exploitation of research results and technology and knowledge transfer organized by KU Leuven research and development (2012). The team of Stijn, Hans, Gergo and Annick won one of the 3 awards for their exploitation plan on biofilm inhibitors.