The MICA Lab studies microbial community behaviour and develops antimicrobials targeting communities.
Our goal is to obtain a better understanding of social interactions in microbial communities, antimicrobial resistance development within communities and methodologies to monitor communities in situ.
This should allow us to develop novel types of antimicrobials that interfere with social interactions (socio-active strategies), resistance development (anti-resistance strategies) or take benefit of improved monitoring (observation-guided strategies). Special attention is paid to the evolution-proof character of the proposed antimicrobial approaches.
The research spans from fundamental investigations of innovative antimicrobial targets, over antimicrobial compound identification and synthesis, to in situ and in vivo testing of novel antimicrobials and strategies for their delivery. To support this research, the MICA Lab is coordinating an interdisciplinary platform for the development of antimicrobials, which is based on several collaborations with research groups within and outside the KU Leuven.