11 October 2023
Competitive interactions facilitate resistance development against antimicrobials
Antimicrobial resistance is one of the most studied bacterial properties due to its enormous clinical and industrial relevance; however, most research focuses on resistance development of a single species in isolation. Luka Svet, Ilse Parijs, Simon Isphording, and Bram Lories showed in a paper published in Applied and Environmental Microbiology that resistance evolution of brewery isolates can differ greatly between single- and mixed-species conditions. Specifically, they observed that the development of antimicrobial resistance in certain species can be significantly enhanced in co-culture as compared to the single-species conditions. Overall, the study emphasizes the need of considering the within bacterial interactions in microbial communities when evaluating antimicrobial treatments and resistance evolution.
16 June 2023
Anomalous diffusion of nanoparticles in the spatially heterogeneous biofilm environment
Nanoparticles are often suggested as a novel antimicrobial delivery strategy. Most of literature has focused on optimalisation of the chemical functionalization of nanoparticles, to improve nanoparticle penetration and antimicrobial efficacy in biofilms. In this work, Tom explored the effect of the biofilm architecture on the efficiency and efficacy on nanoparticle penetration.
13-17 November 2022
9th ASM conference on Biofilms
Gitta elaborated on her work on “combinatorial treatment with antibiotics and the probiotic E. coli Nissle as a strategy to combat biofilms of cooperatively resistant Salmonella Typhimurium” during the 3rd Poster/Networking Session of the conference. Her poster title was "Combinatorial treatment with antibiotics and the probiotic E. coli Nissle as a strategy to combat biofilms of cooperatively resistant Salmonella Typhimurium".
On the same conference, Luka presented the study on the stress response of Salmonella Typhimurium in heterogenous biofilm communities and the implications for the development of antimicrobial resistance. Potential solutions to this problem were outlined. His poster was titled "General stress response of Salmonella Typhimurium in heterogenous biofilm communities as a reaction to ecological competition: implications for the emergence and spread of antimicrobial resistance and potential solutions".
2-4 November 2022
6th Applied Synthetic Biology in Europe (ASBE VI), Edinburgh
Jolien presented a poster (Sharing is caring: Artificially creating different matrix production levels), accompanied by a flash talk, at the ASBE VI in Edinburgh on her efforts to artificially recreate different production levels of biofilm matrix.
At the same conference, Lene presented her work about the importance of probiotic selection and the influence of microbial competition on Salmonella infections in chickens on a poster and flash talk titled: “Angels or demons in the fight against Salmonella : the double edged sword of probiotics in the poultry industry”